Diagnostic Rate of Malignant Lymphoma Using Soluble Interleukin 2 Receptor Levels in Patients with Cervical Lymphadenopathy

Abstract Background and Objectives Cervical lymph node enlargement is observed in various diseases, including malignant lymphoma (ML). Open biopsy of the enlarged frequently required for diagnosis, especially when ML suspected. Serum levels soluble interleukin 2 receptor (sIL-2R) may be useful as a biomarker ML. This study aimed to determine whether measurement serum sIL-2R might diagnose Materials Methods We retrospectively reviewed data 281 patients who had undergone open cervical at our institution between 2015 2019, 157 males 124 females (age range, 5–90 years). Data on patients' age, final were obtained from their medical records. Results Overall, 184 cases MLs 97 other diseases (non-MLs [NMLs]) recorded. The mean age was significantly higher group than NML group. In group, with T cell those B lymphoma. area under receiver operating characteristic curve level predicting 0.711, 1,246 U/mL associated maximum value sensitivity + specificity diagnosis Multivariate analysis revealed that increased 0.758 aged >61 years >1,246 U/mL. Conclusions Among presenting lymphadenopathy, could distinguishing without ML, cutoff